导师简介-侯凯健

侯凯健，男，1980年4月生，副主任医师，医学博士，安徽中医药大学护理学硕士生导师，汕头大学医学院内科学、公共卫生学硕士生导师，汕头大学医学院第一附属医院龙湖医院副院长，汕头市金霞街道社区服务中心主任。现任广东省临床医学会糖尿病专委会副主任委员、广东省预防医学会内分泌分会常务委员、广东省保健协会糖尿病分会常务委员，曾担任美国马里兰州立大学医学中心（巴尔的摩UMMC）临床研究员。主要擅长：糖尿病、高血压、甲状腺、高尿酸血症等疾病的治疗，更是走在国内肠道菌群移植治疗糖尿病领域前沿，且主持国家、省科学基金等多项课题，获得汕头市科学技术奖等。曾发表多篇中文核心论文及专著，并以第一作者（通讯作者）身份在Nature子刊等知名杂志发表SCI论文25篇，最高单篇因子41分。

一、主持的教研、科研项目

1、国家卫生健康委员会卫生经济与政策研究重点实验室项目——肠道菌群移植干预2型糖尿病的卫生技术评估（HTA)。

2、2021年广东省科技厅项目——肠道菌群移植干预自身免疫1型糖尿病的临床研究。

3、汕头市科技局项目——肠道菌群移植对成年2型糖尿病患者的干预治疗。

二、发表论文

[1] Chen F, Hou K, Chen ZS. Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis. Signal Transduct Target Ther. 2022;7(1):284. Published 2022 Aug 13. doi:10.1038/s41392-022-01117-5.    (通讯作者)IF 38.1

[2] He L, Chen R, Zhang B, et al. Fecal microbiota transplantation treatment of autoimmune-mediated type 1 diabetes mellitus. Front Immunol. 2022;13:930872. Published 2022 Aug 12. doi:10.3389/fimmu.2022.930872.    (通讯作者) IF 8.76

[3] Liu W, Wu Z, Sun M, et al. Association between fasting blood glucose and thyroid stimulating hormones and suicidal tendency and disease severity in patients with major depressive disorder. Bosn J Basic Med Sci. 2022;22(4):635-642. Published 2022 Jul 29. doi:10.17305/bjbms.2021.6754.    (通讯作者) IF 3.759

[4] Chen R, Zhu D, Yang R, et al. Gut microbiota diversity in middle-aged and elderly patients with end-stage diabetic kidney disease. Ann Transl Med. 2022;10(13):750. doi:10.21037/atm-22-2926.    (通讯作者)IF 3.893

[5] Chen F, He L, Li J, et al. Polyethylene Glycol Loxenatide Injection (GLP-1) Protects Vascular Endothelial Cell Function in Middle-Aged and Elderly Patients With Type 2 Diabetes by Regulating Gut Microbiota. Front Mol Biosci. 2022;9:879294. Published 2022 Jun 15. doi:10.3389/fmolb.2022.879294.    (通讯作者)IF 6.113

[6] Hou K, Wu ZX, Chen XY, et al. Microbiota in health and diseases. Signal Transduct Target Ther. Apr 23 2022;7(1):135. doi:10.1038/s41392-022-00974-4.    (通讯作者)IF 38.1

[7] Chavda VP, Patel AB, Mistry KJ, et al. Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges. Front Oncol. 2022;12:867655. Published 2022 Mar 29. doi:10.3389/fonc.2022.867655.    (通讯作者) IF 5.738

[8] Wu Q, Yuan F, Zhang S, et al. Correlation of Blood Biochemical Markers with Tardive Dyskinesia in Schizophrenic Patients. Dis Markers. 2022;2022:1767989. Published 2022 Mar 8. doi:10.1155/2022/1767989.    (通讯作者) IF 3.464

[9] Hou K, Zhang S, Wu Z, et al. Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how. Bosn J Basic Med Sci. 2022;22(3):315-325. Published 2022 Jun 1. doi:10.17305/bjbms.2021.6323.    (第一作者) IF 3.759

[10] Wu Z, Chen Y, Zhu D, Zheng Y, Ali KB, Hou K. Advancement of Traditional Chinese Medicine in Regulation of Intestinal Flora: Mechanism-based Role in Disease Management. Recent Pat Anticancer Drug Discov. 2022;17(2):136-144. doi:10.2174/1574892816666210929164930.    (通讯作者) IF 3.038

[11] Liu W, Wu Z, Zhu D, et al. Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials. Front Mol Biosci. 2021;8:799934. Published 2021 Dec 17. doi:10.3389/fmolb.2021.799934.    (通讯作者) IF 6.113

[12] Li J, Chen R, Chen Y, et al. The effect of guar gum consumption on the lipid profile in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials [published online ahead of print, 2021 Sep 24]. Crit Rev Food Sci Nutr. 2021;1-10. doi:10.1080/10408398.2021.1981228.    (通讯作者) IF 11.176

[13] Que Y, Cao M, He J, et al. Gut Bacterial Characteristics of Patients With Type 2 Diabetes Mellitus and the Application Potential. Front Immunol. 2021;12:722206. Published 2021 Aug 12. doi:10.3389/fimmu.2021.722206.    (通讯作者)IF 8.76

[14] Yang L, Hou K, Zhang B, et al. Preservation of the fecal samples at ambient temperature for microbiota analysis with a cost-effective and reliable stabilizer EffcGut. Sci Total Environ. 2020;741:140423. doi:10.1016/j.scitotenv.2020.140423.    (第一作者)IF 10.753

[15] Zhao P, Hou K, Yang S, Xia X. Characterization of small metabolites alteration in mice brain tissues after infected by rabies virus. Infect Genet Evol. 2020;85:104571. doi:10.1016/j.meegid.2020.104571.    (第一作者)IF 4.393

[16] Hou K, Zhao P, Chen Y, et al. Rapid Detection of Bifidobacterium bifidum in Feces Sample by Highly Sensitive Quartz Crystal Microbalance Immunosensor. Front Chem. 2020;8:548. Published 2020 Jul 7. doi:10.3389/fchem.2020.00548.    (第一作者)IF 5.545

[17] Hou K, Chen Y, Zhu D, et al. Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1a  and pERK1/2. Front Biosci (Landmark Ed). 2020;25(11):1974-1984. Published 2020 Jun 1. doi:10.2741/4887.    (第一作者) IF 3.115

[18] Hou K, Ke W, Xiong J. Effect of metformin on the improvement of prostate cancer in diabetic rats. European Journal of Inflammation. 2019;17. doi:10.1177/2058739219858553.    (第一作者)

[19] Hou K, Lin C, Wu B, et al. Exogenetic insulin increased bone mineral densityin middle-aged male patients with type 2 diabetes mellitus. Pak J Pharm Sci. 2015;28(6 Suppl):2227-2230.   (第一作者)

[20] Hong, S., Hou, K., Huang, X., Xu, W., & Chen, Y. (2021). Clinical Study of Early Enteral Nutrition on Acute Gastrointestinal Injury and Sequential Organ Failure. LATIN AMERICAN JOURNAL OF PHARMACY, 40(3), 527-531.   (第一作者)

[21] Zhu, D., Chen, L., Khan, B. A., & Hou, K. (2020). Clinical Management of Concurrent Pulmonary Tuberculosis and Diabetes Mellitus with Individualized Medical Nutrition Therapy. LATIN AMERICAN JOURNAL OF PHARMACY, 39(12), 2458-2462.    (通讯作者)

[22]Qi,X .,Liu,W.,HOU,K.(2022)Antioxidants in Brain Tumors: Current Therapeutic Significance and Future Prospects.Molecular Cancer（通讯作者）（IF 41.144）

三、研究方向

1. 内科学：肠道菌群移植干预糖尿病

2. 公共卫生：流行病与卫生统计学

3. 护理：慢病管理及流行病学、中医体质辨识与护理、伤害预防护理学

四、联系方式

E-mail：kaijianhou1@163.com